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Precision genomic medicine across the Buckeye State. Ohio's unrivaled concentration of world-class medical centers creates a natural proving ground for genomic care delivery at scale.
Ohio is home to an extraordinary density of academic medical centers with established genomic medicine programs — a foundation that makes statewide CarePathway deployment uniquely feasible.
The Center for Genomic Medicine and Genomic Medicine Institute lead the nation in translating genomic discovery into clinical practice. A flagship partner for cardiovascular and multi-system genomic CarePathways.
Nationally ranked among the top three pediatric genetics programs. Home to a world-class human genetics division with deep expertise in NICU rapid sequencing and rare disease diagnosis.
Ohio's flagship academic medical center drives precision oncology and pharmacogenomics research at scale. A natural hub for adult rare disease and oncology genomic CarePathways across central Ohio.
The Steve and Cindy Rasmussen Institute for Genomic Medicine operates one of the largest pediatric genomic sequencing programs in the country, with established rapid genome sequencing in the NICU and PICU.
UH Rainbow Babies & Children's Hospital and the Center for Human Genetics provide comprehensive genetic services across Northeast Ohio, anchoring regional diagnostic networks for rare and undiagnosed disease.
Four CarePathways designed for Ohio's payer and provider landscape — each bundling genetic testing into structured episodes with measurable diagnostic and economic outcomes.
Rapid whole-genome sequencing for critically ill neonates, anchored at Cincinnati Children's and Nationwide Children's. Diagnosis within the admission, measurable LOS reduction, and elimination of the diagnostic odyssey before it begins.
34–59% diagnostic yield · 25% LOS reductionCleveland Clinic leadership in heritable cardiomyopathies, arrhythmias, aortopathies, and familial hypercholesterolemia. Cascade testing transforms a single diagnosis into family-wide risk stratification and prevention.
32–67% diagnostic yield · cascade testingMulti-system diagnostic resolution across Ohio's academic centers. For every two patients tested through a CarePathway, one receives a definitive molecular diagnosis — collapsing years of specialist cycling into a single answer.
~53% avg. yield · 20 organ systemsTumor-normal sequencing and hereditary cancer risk assessment through Ohio State's Comprehensive Cancer Center and Cleveland Clinic's Taussig Cancer Institute. Pharmacogenomic-guided therapy selection reduces adverse events and improves outcomes.
Targeted therapy matching · PGx optimizationGenomic medicine cannot remain confined to urban academic centers. SequenceOH connects Ohio's genomic powerhouses with community health systems, federally qualified health centers, and rural hospitals across all 88 counties.
Ohio's geography presents both opportunity and challenge. The state's five major academic medical centers sit along the I-71 and I-90 corridors, while millions of Ohioans in Appalachian, rural, and underserved communities lack access to specialist genetics services.
CarePathways solve this by creating structured referral networks. A primary care physician in Zanesville or Chillicothe can initiate a genomic workup through a standardized pathway that routes to the appropriate center of excellence, with genetic counseling delivered via telehealth and results interpreted by specialists — without requiring the patient to travel.
The result: diagnostic equity. The same evidence-based genomic evaluation available at Cleveland Clinic or Cincinnati Children's, accessible to every Ohioan regardless of ZIP code.
Academic centers serve as genomic hubs. Community hospitals and FQHCs serve as spokes, initiating CarePathways locally with centralized interpretation.
Pre-test counseling, result disclosure, and follow-up care delivered remotely — eliminating geographic barriers to specialist access across rural Ohio.
Statewide CarePathway data feeds back to payers with measurable endpoints: diagnostic yield, time-to-diagnosis, and downstream utilization reduction.
Dedicated outreach to Ohio's 32 Appalachian counties, where rare disease prevalence is often higher and diagnostic access is lowest.
Whether you are a payer evaluating genomic testing programs, a health system building referral pathways, or a provider seeking structured diagnostic support — SequenceOH connects you with the infrastructure to deliver precision medicine at scale.
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